Oleander treatment refers to using extracts from the plant Nerium oleander as a supposed cancer therapy. 

Some research suggests that the proposed anti-proliferative effects of oleandrin in cancer cells may be associated with its influence on cellular ion regulation, particularly through modulation of Na⁺/K⁺-ATPase activity.

Other studies propose that oleandrin may induce apoptosis in tumor cells through the activation of caspase-3.

To better understand the mechanisms by which oleandrin may induce apoptosis in cancer cells, cultured cancer cell lines are treated with the compound and apoptosis is subsequently assessed using techniques such as flow cytometry.